Case B - Treatment of respiratory diseases (C. sinensis)
Cordyceps sinensis has a long history of treating respiratory diseases and has a very reliable effect. In particular, Cordyceps sinensis has obvious effects on senile chronic bronchitis, respiratory tract infection, chronic cough and asthma, which are common in the elderly. In addition, for pulmonary heart disease, tuberculosis, The treatment of difficult diseases such as silicosis also has a certain effect. At present, the clinical application of Cordyceps sinensis and its fermented hyphal preparations in the respiratory system is also increasingly widespread.
Accustomed to influenza
※Zhao Fengjin and other 10g of Cordyceps sinensis, blisters are used to make tea, and the dregs are roasted and ground into fine powder for oral administration, 2 times a day, 6g each time. rule
1 case of habitual flu, with satisfactory results
2. Respiratory infection
Respiratory tract infections are mainly caused by low immunity and damage to the disease barrier. Chinese medicine believes that it is a deficiency of lung and kidney. Cordyceps sinensis and its fermented mycelium preparations contain a large amount of amino acids and trace elements, which have certain effects on enhancing immunity, improving body functions and preventing respiratory infections.
※Xu Zhiwei and other reports reported that 45 patients with respiratory diseases were randomly divided into Jinshuibao group of 30 cases and Bailing group of 15 cases. Jinshuibao group took Jinshuibao capsules 3 times a day, 5 times a day, 8 cases of Jinshuibao alone, 11 cases of antibiotics in acute phase, 11 cases of traditional Chinese medicine, and 2 cases of Bailing capsules alone. There were 7 cases of antibiotics and 5 cases of Chinese medicine. January is a course of treatment, with four common symptoms, namely cough, sputum, wheezing and snoring as indicators of curative effect: markedly effective (4 indicators improved 3) and effective (4 improved 1~2) Invalid (4 items are not improved). Results Jinshuibao group was effective in 12 cases (40%), effective in 14 cases (46.7%), ineffective in 4 cases (13.3%); Bailing group was markedly effective in 4 cases (26.7%), effective in 9 cases (60.0%), ineffective in 2 cases (13.3%). The total effective rate of the two groups was 86.7%, and the effect was close.
※ Zhao Wei et al. identified the fungal spores as a double infection with sputum culture, and applied Jin Shuibao to prevent double infection. 69 patients with pulmonary infection were randomly divided into the treatment group (n=38) and the control group (n=31). The two groups were treated with conventional therapy. The treatment group was given Jinshuibao capsules three times a day, 3 times a day. Results There were 1 case of double infection in the treatment group and 7 cases in the control group.
※ Zheng Xingyu randomly divided 80 patients with respiratory infection into 30 cases of Cordyceps sinensis decoction group, 26 cases of Cordyceps powder group and 24 cases of levamisole control group. In the decoction group, the winter Cordyceps stew was taken twice a week, 10g each time; the powder group took the summer insecticidal homemade capsules (0.1g per capsule), twice a day, 1.5g each time; the control group took levamisole, and took it 2 days after the week. Medicine for 5 days. All 3 groups were treated for 2 months. Results In the decoction group, 12 cases were effective, 16 cases were effective, 2 cases were ineffective, and the total effective rate was 93.3%. In the powder group, 10 cases were effective, 14 cases were effective, 2 cases were ineffective, and the total effective rate was 92.3%. The control group was markedly effective in 4 cases, effective 13 For example, 7 cases are invalid, and the total effective rate is 70.8%. Statistics show that there is no significant difference between the decoction group and the powder group, and they are better than the control group.
※ Liu Shun'an reported that 4 cases of chronic bronchitis and 2 cases of bronchial asthma were treated with Cordyceps sinensis, and all of them achieved good results. Oral Cordyceps powder 4.5g, 2 times a day, boiled water, 2 months for a course of treatment. The results showed that Cordyceps sinensis had obvious effects of relieving cough, removing phlegm and relieving asthma, and alleviating the onset of bronchial asthma. At the same time, the patient reflected that the tongue coating and pulse of the phlegm stop had corresponding changes.
※Hu Yuheng reported that Chinese and Western medicine treatment of 1 case of chronic asthmatic bronchitis and obstructive pulmonary tumor, uncontrolled, and more and more dramatic, after the use of Cordyceps sinensis 5g, duck (chicken) soup stew, for several days, asthma can be controlled The cough is greatly reduced, the spirit is improved, and the physical strength is enhanced. Under the conditions of climate change, the patient did not have asthma, and the curative effect was exact.
※Wang Juan et al reported a case of a diagnosis of “chronic bronchitis with emphysema” and a 22-year history of TCM
Adopting the method of benefiting Qi and removing phlegm and phlegm and phlegm, the medicine is ginseng and schisandra each 6g, whole melon and salvia are 30g, Qingchao, Ophiopogon,
枳 、, Sichuan Fritillaria each 10g, medlar 15g. After taking 6 doses, the cough was slightly reduced, but the chest tightness, wheezing, shortness of breath still did not ease, and the movement was sweating. Followed by the addition of Cordyceps sinensis 3g, the end of the split into the lungs to protect the lungs and kidney, gas and asthma. After 1 week of treatment, the symptoms of chest tightness and asthma were significantly improved. The sweat was stopped, and the edema of the lower extremities subsided. Later, he changed to a single-flavored Cordyceps sinensis 3g/d, and he was divided into three groups according to the anti-infective treatment of western medicine for 28 days, and his condition was relieved and discharged. In addition, a patient with a 30-year history of bronchial asthma diagnosed as "asthma syndrome" was treated with Yiqi Yangyin, Wenshen Gushui, Naqi Pingchuan, medicinal ginseng, hawthorn meat, and phlegm 20g of Ling magnetic magnet, 15g of Radix Pseudostellariae, 10g of Schisandra, Ophiopogon japonicus and Scorpion, and the effect of taking 6 doses is not good. Asthma attacks are frequent and continue to be incomprehensible. After the addition of Cordyceps sinensis 3g, the end of the study was divided into 10 minutes, asthma was controlled, no sweat, and limbs turned warm. After continuing treatment for 1 month, the condition was stable and discharged after physical recovery.
※Zhang Xiuhua et al. randomly divided 100 patients with chronic bronchitis or arrhythmia into 50 patients in the treatment group and the control group. The treatment group was given Cordyceps capsules on the basis of conventional treatment (the Cordyceps fermented mycelium preparation, Jining Antibiotic Factory). ), 3 times a day, 2 capsules each time, 30 days for a course of treatment. The results showed that Cordyceps capsules had good antitussive and antiasthmatic effects, as shown in Table 8-1.
※ Zheng Liye and other randomized 35 patients with chronic bronchitis were divided into treatment group 20 cases, oral Jinshuibao capsules, 3 times a day, each time
Granules; 15 cases in the control group, oral vitex oil pills, 3 times a day, 2 capsules each time. Take 1 month as a course of treatment, with cough, expectoration, etc.
Efficacy criteria. Results In the treatment group, 7 cases were clinically controlled, 10 cases were markedly effective, 2 cases were improved, 1 case was ineffective, and the total effective rate was 95.0%. The clinical control of the face control group was 0 cases, 2 cases were markedly effective, 5 cases were improved, 8 cases were ineffective, and the total effective rate was obtained. 46.6%. It shows that Jinshuibao capsule has significant curative effect on chronic bronchitis, especially simple type.
※ Ni Xiaomei divided 164 patients with chronic bronchitis into 84 cases of Jinshuibao group and 80 cases of nuclear cheese group. Both groups were taken after acute attack control or before the onset season from July to September every year. Jinshuibao group oral Jinshuibao capsules, 3 times a day, 3 capsules each time; nuclear cheese group each 20ml, 2 each time, 2 times a week, intramuscular injection. All patients were treated as a course of treatment in March. After the treatment, they were followed up for 1 year. The improvement of cough, phlegm, asthma and lung snoring was used as the standard of curative effect. Results Jinshuibao group was effective in 33 cases, improved in 40 cases, ineffective in 11 cases, the total effective rate was 86.9%, the nuclear case group was markedly effective in 28 cases, improved in 30 cases, and ineffective in 22 cases, the total effective rate was 72.5%.
※ Shi Xiangming applied Jinshuibao Capsule and Hefeibao 3 tablets to treat 120 cases of chronic bronchitis. In the treatment group, Jinshuibao capsules were added to the control group for 3 tablets (3 times a day, 1-2 tablets each time), 3 times a day, 3 capsules each time. Both groups were treated with 30d for a course of treatment, and even 1-4 courses of treatment, with the improvement of cough, phlegm, asthma and wheezing as the standard of efficacy. Results In the treatment group, 42 cases were clinically controlled, 36 cases were markedly effective, 36 cases were improved, 6 cases were ineffective, the total effective rate was 95%, and the control rate was 65%. In the control group, 20 cases were clinically controlled, 18 cases were markedly effective, 56 cases were improved, and 26 cases were ineffective. The total effective rate was 78.3%, and the control rate was 31.7%.
※裘雨林 For 168 patients with chronic bronchitis prolonged period, Jinshuibao capsules were taken from July every year in April, 3 times a day, 3 capsules each time. Results 42 cases were clinically controlled, 48 cases were markedly effective, 51 cases were effective, 27 cases were ineffective, and the total effective rate was 83.9%.
※Zhu Tieying and other chronic bronchitis, which is a syndrome of lung qi deficiency and kidney yang deficiency, is based on the Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine.
Phase II clinical trials were carried out on the foxtail fungus powder capsules. A total of 110 cases were observed, including 80 cases in the treatment group and 30 cases in the control group. The course of treatment was 9 days, and 1-3 courses were observed. During the observation period, any antitussive, expectorant, lung, kidney and asthma effects were stopped. Chinese and Western medicine. Oral Cordyceps mycelium capsules 3 times a day, 4 capsules each time (0.2g per capsule), warm water delivery service, the results of clinical control 29 cases (36.25%), markedly effective 22 cases (27.50), effective 24 cases (30.00%) Ineffective, 5 cases (6.25%), the total effective rate was 93.75% (P <0.01), indicating that the treatment group was significantly better than the control group; the treatment group improved the main symptoms and signs, such as cough, mouth and lung snoring The aspects were superior to the control group (P<0.05), but the difference between the two groups was not significant (P>0.05). Through the comparison of the efficacy of TCM syndrome differentiation between the 2 groups and the 2nd grade, the treatment group was superior to the control group regardless of lung qi deficiency or kidney yang deficiency. The results are shown in Table 8-2. The white blood cell count of the treatment group was significantly lower than that of the control group. -3; Comparison of lung function FEV1 and PEFR before and after treatment by the treatment group showed that the drug had a certain improvement effect on lung ventilation function, and the results are shown in Table 8-4.
※Zhang Yingping conducted clinical observations on 65 patients with chronic bronchitis and cold syndrome of lung qi deficiency and kidney yang deficiency. The clinical control rate of treatment results was 50.8% and the effective rate was 9.2%. The improvement rate was 32.3%, and the total effective rate was 92.3%. It shows that Cordyceps militaris powder capsule can significantly improve the symptoms and signs such as cough, cough, wheezing and wheezing, and its good curative effect is also reflected in the changes of tongue and pulse of patients, without any adverse effects on hematopoietic function and liver and kidney function. No other obvious adverse reactions were found in the clinic.
4. Bronchial asthma
Chinese medicine believes that asthma is repeated for the lungs as the standard, kidney-based. Repeated attacks of asthma, prolonged unhealed, lung disease and kidney, will inevitably lead to lung gas dissipation, kidneys are not gas. Expelling the lungs to strengthen the qi, the gas to the kidney, cough and asthma. Thereby achieving the basis of regulating the viscera, relieving asthma and reducing the stress.
※裘雨林 and other 50 patients with cough-type asthma were randomly divided into the treatment group of 32 cases and the control group of 18 cases. The treatment group was given Jinshuibao capsules on the basis of oral ketotifen and astems in the control group, 3 times a day. Each time 3 capsules, 2 groups were treated with 10d for 1 course. Results In the treatment group, 16 cases (50%) were effective, 10 cases (31.3%) were effective, 6 cases (18.7%) were ineffective, and the total effective rate was 81.3%; the control group was effective in 6 cases (3.3%), and the effective rate was 5 cases (27.8%). Invalid 7 cases (38.2%), the total effective rate was 61.1%. Statistical processing, total efficiency of 2 groups
The difference was significant (P<0.05). The oral side reaction of Jinshuibao Capsule was mild. Only 2 cases had a burning sensation in the upper abdomen after oral administration. The oral symptoms disappeared after changing the meal.
※ Wu Xinghe randomly divided 94 patients with asthmatic asthma into 64 patients in the treatment group and 30 patients in the control group. The treatment group was given Bailing capsules on the basis of oral administration of aminophylline, dexamethasone tablets and fluoxazine tablets. 3 times a day, 5 capsules each time, 2 groups were treated with 14d for 1 course. Results In the treatment group, 35 cases (54.68%) were markedly effective, chest tightness, cough, asthma symptoms disappeared, night energy was supine, FEV1 was increased compared with before treatment (≥20%); effective 21 cases (32.81%), chest tightness, cough, asthma symptoms Significantly alleviated, FEV increased compared with before treatment (15% ≤ FEN1 <20% 6); 8 cases (1250% 6) were ineffective, chest tightness, cough, asthma symptoms were not alleviated, FEV was slightly increased compared with before treatment (<15 %), the total effective rate was 87.49%, the average time of remission was 6d; the control group was markedly effective in 11 cases (36.66%); the effective 8 cases (26.67%);
For example (36.67%), the total effective rate was 63.33%, and the relief time was 10d on average. Statistical analysis, the total effective rate difference between the two groups was significant (P<
0.05). There was no obvious side effect of Jinshuibao Capsules. Only 3 cases had loose stools. One case had pain in the upper abdomen and one case was accompanied by sleeplessness.
Bronchiectasis is a common chronic suppurative disease, due to repeated infections, repeated attacks, and how long it takes to cure.
※ Wu Haiqi et al reported that 24 patients with bronchiectasis were randomly divided into treatment group (n=14) and control group (n=10). The treatment group was treated with Jinshuibao capsules on the basis of control infection and symptomatic treatment in the control group, 3 times a day, 4 times each time. 6 capsules, even for June. After 2 years of follow-up, cough, hemoptysis, snoring, and lesion absorption were used as the standard of efficacy. Results In the treatment group, 4 cases were markedly effective, 7 cases were improved, 3 cases were ineffective, and the total effective rate was 78.57%. The control group was markedly effective in 0 cases, improved in 4 cases, ineffective in 6 cases, and the total effective rate was 40%.
6. Chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incomplete reversible airflow limitation. The condition is often progressively aggravated, with high mortality and an upward trend. At present, there are no effective therapeutic drugs for clinical use in the clinic, mainly for anti-infection, dilatation of bronchus and application of hormones.
※Wu Jiarong and other applied Cordyceps capsules (C. sinensis fermenting hyphae 832-A, Institute of Naval Medicine) for 25 cases of chronic obstructive
Clinical efficacy was observed. The oral dose is 2-3 capsules per time, 3 times a day. Taking medicine for 3-4 months, preliminary observation can improve the disease
Shape, reduce the number of colds and the number of episodes of the disease. The total curative effect was 3 cases with close control, 6 cases with obvious control, 10 cases with improvement, and 1 case with ineffectiveness. The effective rate was 36% and the effective rate was 96%. The cough, expectoration, asthma and snoring were all improved. The effective rate was 72%. -96%; the number of cold attacks, 12 cases were significantly reduced, 8 cases were reduced, 5 cases were unchanged; the number of cases reached 1 case of near-control, 7 cases of marked improvement, 13 cases of improvement, and 4 cases of no change. Taking Cordyceps capsules, there are different degrees of gradual reduction with the improvement of symptoms, and other drugs such as antibiotics and cough and phlegm drugs are also reduced. The OT test was enhanced in different degrees after treatment, and was significantly enhanced in 6 cases, 2 cases were enhanced, and 1 case was unchanged. The lymphocyte transformation rate and rosette test rose to the normal range after treatment, indicating that the use of Cordyceps capsules can promote The cellular immune function was enhanced; 15 cases of immunoglobulin did not change significantly after treatment; 18 cases of patients had significantly increased cAMP after treatment (P < 005), while cGMP showed a downward trend, and the cAMP/cGMP ratio increased before and after treatment. 1.62+1.95, 3.88+3.51 (pc0.05); serum lysozyme increased significantly before and after treatment (6.58±1.90) mg/ml, (9.43±3.38) mg/ml (P<0.01). The clinical results confirmed that Cordyceps sinensis and its fermented hyphae have the function of activating macrophage system, enhancing T cell function, and enhancing and regulating the body's immune function.
※Wang Weiquan reported that 35 patients with chronic cold-resistant emphysema were treated with anti-infection, antiasthmatic and expectorant in the acute phase.
After that, Jinshuibao capsules were given 3 times a day, 3 capsules each time, and 214 was a course of treatment. The results showed that after treatment, the patient's cough and gasping improved significantly, the sputum decreased or even disappeared, and the mental, appetite and lung signs improved accordingly, and the SOD value increased from 1318.26±444.96 to 1844.55±5039, the difference was significant (P<0.001). .
※Zhou Qingbin reports 60 cases of chronic obstructive pulmonary disease with lung and kidney deficiency